Thus, pregnant mice exposed to 2-acetylaminofluorene excrete acetyl-N-glucosides, acetyl-N-sulphates and N-acetyl-4-aminofluorene. The acetyl group is lost from N-acetyl-2-aminofluorene during glucuronidation. There was a more than two-fold increase in the urinary level of N-acetyl-4-amino-2-nitrofluorene in 2-acetylaminofluorene-treated pregnant mice. After 2-acetylaminofluorene treatment (100 mg/kg body weight) during pregnancy, the following metabolites were identified: N-acetyl-2-aminofluorene, N-acetyl-4-amino-2-nitrofluorene, N-acetyl-2-aminofluorene-N-glucoside, N-acetyl-2-aminofluorene-4-sulphate, and the sum of acetyl-N-glucosides, acetyl-N-sulphates and N-acetyl-4-aminofluorene. Urinary metabolites of 2-acetylaminofluorene were identified and quantitated in pregnant and non-pregnant control and 2-acetylaminofluorene-treated mice.
KIFV.The metabolism and urinary excretion of the rat tumour-promoting carcinogen, 2-acetylaminofluorene, in pregnant mice.
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